Single Or More
Flute selection with end-mills offers the same challenges as with drills and taps.  Flute selection is normally a matter of compromise between available chip space and strength of the remaining core of the tool.  Obviously, deeper and wider flutes make a smaller diameter core cross-section, which becomes sometimes unacceptably weaker.  Providing a stronger, thicker core reduces space available in the flutes for chips. Considerations include:
  •  Softer materials can be done with deep wide flutes/thinner cores.
  •  Harder materials require a thicker core but benefit from more flutes.
  •  Three flutes can have almost as much chip space as 2 flutes, but stronger cores.
  •  Aggressive helix angles can eject chips rapidly, reducing the need for wide, deep flutes.
  •  More flutes/lands yield better finishes.
With increasing the number of flutes, you do have the opportunity to increase production. (IPM)
The calculation for this is: RPM X IPT (feed per tooth) x # Flutes (cutting teeth) = IPM
Example: Milling stainless steel 50 SFM at 381 RPM'S at .002 IPT
2 Fluted mill: 381 RPM'S x .002 IPT x 2 Flutes  = 1.524 IPM
3 Fluted mill: 381 RPM'S x .002 IPT x 3 Flutes  = 2.286 IPM
4 Fluted mill: 381 RPM'S x .002 IPT x 4 Flutes  = 3.048 IPM